Which of the following is TRUE regarding pituitary growth hormone (GH)?
A. GH exerts negative feedback on its own production by inhibiting the hypothalamic secretion of somatostatin.
B. GH increases the sensitivity of tissues to the action of insulin.
C. The liver produces a factor that mediates the metabolic actions of GH.
D. GH stimulates insulin-like growth factor-1 (IGF-1) production by the liver and by many other cells.
E. IGF-1 stimulates the secretion of GH by anterior pituitary gland cells.
Answer: D
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