When explaining how verapamil (Calan) produces its effects on the cardiovascular system, which of the following would the nurse integrate into the explanation? Select all that apply
A) Reduction in the release of renin
B) Dilation of coronary arteries
C) Dilation of peripheral arteries
D) Slowed conduction through the SA and AV nodes
E) Membrane-stabilizing effects
Ans: B, C, D
Feedback:
Verapamil (Calan) is a calcium channel blocker. These drugs inhibit the movement of calcium through channels across the myocardial cell membranes and vascular smooth muscle. Cardiac and vascular smooth muscle depends on the movement of calcium ions into the muscle cells through specific ion channels. When this movement is inhibited, the coronary and peripheral arteries dilate, thereby decreasing the force of cardiac contraction. This drug also reduces heart rate by slowing conduction through the SA and AV nodes.
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