In which of the following patients, would diagnostic investigations least likely reveal increased thrombopoietin production?
A)
An 81-year-old woman with diagnoses of rheumatoid arthritis and failure to thrive
B)
A 55-year-old man with dehydration secondary to Crohn disease
C)
A 66-year-old woman with a diagnosis of lung cancer with bone metastases
D)
A 21-year-old woman awaiting bone marrow transplant for myelogenous leukemia
Ans:
D
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Diseases such as myelogenous leukemia and other cases of primary thrombocytosis result in abnormalities in the thrombopoietin receptor and platelet binding. Cases of secondary thrombocytosis have an etiology rooted in increased thrombopoietin production. The common underlying causes of secondary thrombocytosis include tissue damage due to surgery, infection, cancer, and chronic inflammatory conditions such as rheumatoid arthritis and Crohn disease.
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