For patients with bipolar disorder, valproate anticonvulsants are likely to help control rapid-cycling episodes by

a. inhibition of kindling activity in the brain.
b. decreasing availability of norepinephrine.
c. increasing dopamine levels at synapses.
d. decreasing GABA metabolism.


A
The effectiveness of valproate anticonvulsants for management of bipolar disorder may be related to inhibition of kindling activity, which stabilizes neuronal activity and increases the threshold of stimulation necessary for cell firing. There is no current research to support any of the other options.

Nursing

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