The folk singer, Woody Guthrie, died of Huntington's chorea. One of his parents also died of this disease affecting the nervous system
The disease usually affects carriers between 25 and 45 years of age and is inherited as a Mendelian autosomal dominant trait. Using Punnett squares, determine the probability that any of the three Guthrie offspring will have this devastating disease.
What will be an ideal response
Woody had to have been a heterozygote Hh for the allele because the dominant homozygous condition is lethal to the fetus. Woody's wife did not have the disease so she was not carrying it. Genetically they were Hh × hh. Using a Punnett square, the probability of having a child with the disease would be 50%.
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