The MD has decreased the patient's dose of daily aspirin and recommended discontinuing his ibuprofen. Why? How might aspirin and other NSAIDs affect gastroesophageal disease?
What will be an ideal response?
• Both of these medications can result in gastritis.
• Aspirin and NSAIDs cause gastrointestinal disease by 2 independent mechanisms:
• topical injury to the mucosa and
• systemic depletion of cytoprotective prostaglandins.
• Decreasing the aspirin dosage can allow it to provide cardiovascular protection while minimizing its toxic effect on the gastric mucosa
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