What would be the consequence if terminal deoxynucleotidyl transferase (TdT) were expressed throughout the whole of small pre-B-cell development?
What will be an ideal response?
N nucleotides would be added at the VJ joints of all rearranged light-chain genes during gene rearrangement (instead of about half), resulting in an increase in immunoglobulin diversity. It is interesting to note that because TdT is not expressed until after birth, B-1 cells that are generated prenatally lack N nucleotides in the VD and DJ junctions of their rearranged heavy-chain genes as well as in the VJ junctions of all light-chain genes.
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