In the general population, 1 in 300 individuals is a carrier for Tay-Sachs disease, while 1 in 30 individuals of Ashkenazi Jew descent are carriers
Tay-Sachs also affects 1 in 30 individuals with French-Canadian ancestry, although two completely unique mutations are responsible for the Ashkenazi and French-Canadian mutations. What are the chances of two individuals who are carriers having a child with Tay-Sachs if a. both individuals are not of Ashkenazi or French-Canadian descent? b. one individual is of Ashkenazi descent and one is not? c. both individuals are of Ashkenazi descent?
For each question, you will calculate
[Chance of mom being a carrier] × [Chance of dad being a carrier] × [Chance of having an affected child if both parents are carriers]
a. (1/300 ) × (1/300 ) × 1/4 = 2.77 × 10–6
b. (1/30 ) × (1/300 ) × 1/4 = 2.77 × 10–5
c. (1/30 ) × (1/30 ) × 1/4 = 2.77 × 10–4
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