A nurse should monitor a client taking which of the following drugs for increased adverse effects and toxicity if omeprazole (Prilosec) therapy is initiated? Select all that apply
A) Phenobarbital (Luminal)
B) Digoxin (Lanoxin)
C) Diazepam (Valium)
D) Warfarin (Coumadin)
E) Ketoconazole (Nizoral)
Ans: B, C, D
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The initiation of proton pump inhibitors, like omeprazole (Prilosec), can result in increased adverse reactions and toxicities of warfarin (Coumadin), benzodiazepines (diazepam), digoxin (Lanoxin), phenytoin (Dilantin), and clarithromycin (Biaxin).
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