If the gp120 glycoprotein were damaged as a result of a mutation, HIV would have difficulty:
A. binding to a host cell
B. leaving a macrophage
C. inserting its genes into the host cell's genome
D. assembling the capsid
E. attaching its RNA to a host cell's ribosome
Clarify Question
· What is the key concept addressed by the question?
· What type of thinking is required?
Gather Content
· What do you already know about HIV infection?
Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
A. binding to a host cell
Clarify Question
· What is the key concept addressed by the question?
o This question addresses HIV infection.
· What type of thinking is required?
o This question is asking you to take what you already know and apply it to this unfamiliar situation.
Gather Content
· What do you already know about HIV infection?
o HIV infects key immune-system cells: macrophages and T cells.
o The viral glycoprotein gp120 precisely fits on the cell-surface marker protein CD4+ on those cells. When HIV attaches to two receptors CD4+ and CCR5, it is able to pull itself across the cell membrane and enter the cell.
Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
o The gp120 glycoprotein binds to the CD4+ protein on the surface of macrophages and T cells, allowing the HIV virus to enter the cell.
o So if it was mutated, it would not be able to bind to the host cell, and that would prevent viral entry.
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
o The question required you to take what you already know and apply it to this unfamiliar situation.
o Did you recognize that the gp120 glycoprotein binds to the CD4+ cell-surface marker protein on macrophages and T cells, allowing viral entry?
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