Which patient, when compared with the general population, would require a larger dose or more frequent administration of a drug to attain a therapeutic response?
a. A 29-year-old who has been diagnosed with kidney failure
b. A 35-year-old obese male who is being evaluated for an exercise program
c. A 52-year-old diagnosed with hypothyroidism and decreased metabolic rate
d. A 72-year-old with decreased circulatory status
ANS: B
An obese individual would require a larger dose of a drug to attain a therapeutic response. An individual with kidney failure would require less medication because of decreased excretory ability. Individuals with decreased metabolic rate would metabolize drugs more slowly and require smaller doses or less frequent administration. Individuals with decreased circulation would require less medication.
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