A client newly diagnosed with depression is given a prescription for an antidepressant. The nurse understands that the medication prescribed affects which neurotransmitter that is associated with anxiety, impulsive behavior, and suicidal ideation?
1. Glutamate
2. Serotonin
3. Dopamine
4. Acetylcholine
Correct Answer: 2
Rationale 1: Glutamate is an excitatory neurotransmitter associated with memory.
Rationale 2: Low serotonin levels in the CNS are associated with anxiety and impulsive behavior, including suicidal ideation. Serotonergic receptors play an important role in the mechanism of action of antidepressant drugs.
Rationale 3: Dopamine is associated with Parkinson disease, psychoses, motivation, and pleasure.
Rationale 4: Acetylcholine is associated with myasthenia gravis and Alzheimer disease.
Global Rationale: Low serotonin levels in the CNS are associated with anxiety and impulsive behavior, including suicidal ideation. Serotonergic receptors play an important role in the mechanism of action of antidepressant drugs. Glutamate is an excitatory neurotransmitter associated with memory. Dopamine is associated with Parkinson disease, psychoses, motivation, and pleasure. Acetylcholine is associated with myasthenia gravis and Alzheimer disease.
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