Which statement most accurately describes the cell kill hypothesis?
1. It is a model that predicts the amount of normal cells that will be affected by antineoplastic drugs.
2. It is a model that predicts the ability of antineoplastic drugs to eliminate cancer cells.
3. It is a model that predicts how invasive a cancer has become.
4. It is a model that compares the appearance of potential cancer cells with that of normal parent cells.
Correct Answer: 2
Rationale 1: This statement does not describe a particular model.
Rationale 2: This statement describes the cell kill hypothesis.
Rationale 3: This statement describes staging.
Rationale 4: This statement describes grading.
Global Rationale: The cell kill hypothesis is a theoretical model that predicts the ability of antineoplastic drugs to eliminate cancer cells. This hypothesis predicts that a drug will kill a certain percentage, rather than a constant number, of cancer cells. It does not predict the number of normal cells that will be affected. Staging gauges invasiveness. Grading compares cancerous cells to normal cells.
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