What is the earliest manifestation of diabetes-induced kidney dysfunction?
a. Polyuria
b. Glycosuria
c. Microalbuminuria
d. Decreased glomerular filtration
ANS: C
Polyuria occurs due to increased fluid in the vascular space, and microalbuminuria is the earliest manifestation. While glycosuria occurs due to hyperglycemia, it is not the first sign of kidney dysfunction. Decreased glomerular filtration and polyuria can occur due to changes, but neither are initial manifestations.
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