A single infusion of antithymocyte globulin can reduce the lymphocyte by:
1. 85–90%.
2. 60–70%.
3. 40–50%.
4. 50–60%.
Correct Answer: 1
Rationale 1: A single dose can decrease lymphocytes by 85–90%.
Rationale 2: This percentage of reduction is not indicative of the effectiveness of antithymocyte globulin.
Rationale 3: This percentage of reduction is not indicative of the effectiveness of antithymocyte globulin.
Rationale 4: This percentage of reduction is not indicative of the effectiveness of antithymocyte globulin.
Global Rationale: Antithymocyte globulin consists of polyclonal antibodies obtained from the serum of horses (Atgam) or rabbits (Thymoglobulin) exposed to human T cells. The drug is a potent immunosuppressant used for the prophylaxis and management of transplant rejection and for the treatment of moderate to severe aplastic anemia in patients who are unable to have bone marrow transplantation. A single infusion may lower the lymphocyte count by 85% to 90%.
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