Which medications are not effective in the immediate treatment of acute anaphylaxis?
a. Epinephrine c. Diphenhydramine (Benadryl) IV
b. Vasopressors d. Corticosteroids
D
Epinephrine is the first-line treatment of choice for anaphylaxis and should be administered when initial signs and symptoms occur. Several medications are used as second-line adjunctive therapy. Inhaled ?-adrenergic agents are used to treat bronchospasm unresponsive to epinephrine. Diphenhydramine (Benadryl) given 1 to 2 mg/kg (25–50 mg) by a slow intravenous line is used to block histamine response. Ranitidine, given in conjunction with diphenhydramine at a dose of 1 mg/kg intravenously over 10 to 15 minutes, has been found helpful. Corticosteroids are not effective in the immediate treatment of acute anaphylaxis but may be given with the goal of preventing a prolonged or delayed reaction.
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