A primary care NP is prescribing a drug for a patient who does not take any other medications. The NP should realize that:
a. CYP450 enzyme reactions will not interfere with this drug's metabolism.
b. substrates such as alcohol cannot interfere with the drug when the patient is abstaining.
c. food-drug interactions are limited to those where food enhances or inhibits drug absorption.
d. a thorough history of diet, alcohol use, smoking, and over-the-counter and herbal products is required.
D
Drugs are not the only substances that interfere with drug kinetics and dynamics. The primary care NP should conduct a thorough history of food and alcohol intake, smoking, and over-the-counter and herbal supplements to identify things that might interfere with a drug. All of these may interfere with CYP enzymes. Alcohol intake can influence this even when the patient is abstaining because of long-term effects on the liver.
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The nurse is caring for a client in the long-term care facility that was living in their home with a family member caring for them
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