Thalassemia is a recessive blood disease caused by reduced synthesis of one of the globin genes
While SCD is a mutation in the structure of hemoglobin, thalassemias can also be caused by mutations in the regulatory elements, causing too little globin to be produced and resulting in anemia. You've designed a DNA probe that you want to use to screen a family for a rare mutation in the ?-globin gene that causes thalassemia. First you will use the probe for northern blotting. What information will the northern blot tell you? A) whether the mRNA for ?-globin is being translated into functional proteins in a given cell population
B) whether the amount of the ?-globin gene being transcribed (mRNA levels) is within normal range
C) the size of the mRNA being transcribed
D) the presence of a particular mutation by restriction fragment analysis
E) both B and C are correct
E
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