The nurse is caring for a patient who begins to complain of shortness of breath. Upon further assessment, the nurse notes 3+ pitting edema bilaterally in the lower extremities
Which medication taken by the patient would most concern the nurse with regard to these findings?
a. Epoetin alfa
b. Oprelvekin (interleukin-11)
c. Filgrastim (granulocyte colony–stimulating factor)
d. Sargramostim (granulocyte-macrophage colony–stimulating factor
ANS: B
Oprelvekin causes the kidneys to retain sodium and water, which causes peripheral edema and expansion of plasma volume. Some patients experience dyspnea.
Fluid retention is not an adverse effect of epoetin alfa, filgrastim, or sargramostim.
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