Cross Bridge Formation
What will be an ideal response?
A) Calcium ion binds to troponin
B) Tropomyosin moves away revealing active site
C) Myosin head MUST BE ACTIVATED BEFORE - This occurs when ATP binds to the myosin head and is hydrolyzed to ADP and inorganic phosphate. The energy liberated from the hydrolysis of ATP activates the myosin head, forcing it into the cocked position.
In general 4 steps:
1- Cross Bridge Formation - activated myosin binds to actin forming a cross bridge
2- Power Stroke - ADP is released and the activated myosin head pivots, sliding the thin myofilament toward the center of the sarcomere
3- Cross Bridge Detachment - ATP binds to the myosin head weakening the bond with the active site and it detaches
4- Reactivaton - see step #3
This continues as long as the calcium binds to troponin, moving tropomyosin away from the active site.
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