The third hypervariable region (CDR3) is the most variable site in an immunoglobulin V region. It differs in its composition between the light-chain and heavy-chain V regions
Explain what this difference is and how the diversity in CDR3 is generated.
What will be an ideal response?
CDR3 of the light chain is composed mainly of the coding joint between the V and J segments, which is formed during somatic recombination, with junctional diversity being generated by the addition of P and N nucleotides. CDR3 of the heavy chain is composed mainly of the D gene segment plus its coding joints with a V gene segment on one side and a J gene segment on the other. P and N nucleotides are also added to these joints during recombination. In addition, the D gene segment sequences differ between immunoglobulins.
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