A 27-year-old woman arrives at the emergency department with acute bleeding and is found to have a white count of 25.7 x 109L with pancytopenia: hematocrit 27%, platelet count 35 x 109/L, and absolute neutrophil count 0.8 x 109/L
She has a combination of 97% blasts and abnormal promyelocytes in her peripheral blood; some of these cells contain stacked Auer rods. What form of leukemia does she most likely have?
a. Acute myeloid leukemia with t(15;17)(q22:q12)
b. Chronic myeloid leukemia
c. Acute monoblastic leukemia
d. Acute myeloid leukemia with t(8;21)(q33:q22)
ANS: A
Acute myeloid leukemia with t(15;17)(q22:q12) is characterized by abnormal promyelocytes, which may have stacked Auer rods. Patients are most often young adults. When bundles of Auer rods are found in a cell, they are called faggot cells.
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