A 68-year-old man developed severe progressive muscular weakness. He also had difficulty swallowing and ultimately died of respiratory failure. Loss of cortical motor neurons and lower motor neurons was seen at autopsy. The most likely diagnosis is
A. leukodystrophy
B. Pick's disease
C. Parkinson's disease
D. Wernicke's encephalopathy
E. amyotrophic lateral sclerosis
E
Progressive muscle weakness with dysphagia and paralysis of respiratory muscles is indicative of motor neuron disease, and the autopsy findings confirmed that the patient had amyotrophic lateral sclerosis.
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