Which of the following is a mechanism of action of nonsteroidal anti-inflammatory drugs?
a. inhibition of prostaglandin synthesis
b. inhibition of platelet synthesis
c. increase in bradykinin
d. increase in thromboxane
a. NSAIDs inhibit prostaglandin synthesis (primarily PGE2) by inhibiting the cyclooxygenase enzymes, resulting in a reduction of inflammation. However, similar to aspirin, they inhibit both COX-1 and COX-2, resulting in many adverse effects because COX-1 has a protective role on the GI mucosa and kidneys. Inhibition of COX-2 in tissues is responsible for the anti-inflammatory effects of NSAIDs.
You might also like to view...
The 2009 National Emergency Medical Services Education Standards: Paramedic Instructional Guidelines provide for a much improved understanding of the ____________ of various illnesses and injury processes
Fill in the blank(s) with correct word
If a check is NOT presented for payment within the time suggested on the check, it is considered a ________ check.
A. cashed B. voided C. stale D. returned
The correct method to convert a ratio to a percentage is to ____.
A. divide the fraction, multiply the quotient by 100, and add a percent sign B. divide the fraction C. multiply the fraction, divide the quotient by 100, and add a percent sign D. multiply the fraction
A court order to produce documents is ____.
A. respondeat superior B. subpoena C. subpoena duces tecum D. subpoena testificandum E. law of agency