Glucose-6-phosphate dehydrogenase (G6PD) is:
a. An extremely rare enzyme deficiency
b. Necessary to maintain reduced glutathione in the mature red cell
c. Important for the production of ATP in the mature red cell
d. Important for the transport of carbon dioxide by the mature red cell
ANS: B
G6PD is an enzyme in the hexose monophosphate pathway and is important to maintain reduced glutathione in the red cell. This substance (reduced glutathione) is critical for preventing oxidative damage to red cell proteins. This pathway does not produce any energy and has no function in carbon dioxide transport. Its deficiency is very common worldwide, affecting millions of people; in fact, it is the most common human enzyme deficiency in the world.
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