Mr. Jones recently started taking a medication called an ACE inhibitor. He called his doctor's office to ask why this medicine makes him light-headed and dizzy and learned these are symptoms related to low blood pressure. Explain to Mr. Jones why the ACE
inhibitor would cause low blood pressure.
What will be an ideal response?
Angiotensin-converting enzyme (ACE) converts angiotensin-I to angiotensin-II (A-II) as part of the renin-angiotensin-aldosterone system (RAAS). A-II promotes vasoconstriction of systemic blood vessels to increase systemic blood pressure and efferent arterioles to increase glomerular hydrostatic pressure (GHP). In the proximal tubule, A-II promotes reabsorption of sodium and chloride ions from the filtrate. These effects cause blood volume to increase and blood pressure to increase. If ACE is inhibited, both blood volume and systemic blood pressure are lowered.
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