The patient is admitted to the hospital in chronic renal failure, and is on several medications. What best describes the nurse's assessment of this patient?
1. The patient's liver may compensate for renal failure; the drugs may be effective.
2. The patient may have drug toxicity from all the drugs.
3. The patient may have drug toxicity only if the drugs are excreted by the kidneys.
4. The patient may have decreased effectiveness of the drugs.
Correct Answer: 2
Rationale: Since the kidneys are the primary route of excretion for many drugs, chronic renal failure puts the patient at risk for drug toxicity. The patient in chronic renal failure will more likely have drug toxicity than decreased effectiveness of the drugs. The liver cannot compensate for renal failure; the patient is at risk for drug toxicity. Since the majority of drugs are excreted by the kidneys, the patient will most likely have drug toxicity.
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