A woman who wishes to become pregnant is concerned about the drugs she must take in order to treat a serious medical condition. The nurse reviewing the drug list would be most concerned about which kind of drug?
1. A drug with a long half-life
2. A drug with no active metabolites
3. A drug with high protein-binding ability
4. A drug taken only when needed
1
Rationale 1: Drugs with long half-lives should be avoided because they can accumulate in the infant's plasma.
Rationale 2: Drugs with active metabolites should be avoided because they can accumulate in the infant's plasma.
Rationale 3: Drugs with high protein-binding ability are not secreted as readily to the milk.
Rationale 4: If a drug is taken on an as needed basis, the woman could schedule the drug to be taken immediately after breast feeding.
Global Rationale: Drugs with long half-lives or active metabolites should be avoided because they can accumulate in the infant's plasma. Drugs with high protein-binding ability are not secreted as readily to the milk. If a drug is taken on an as needed basis, the woman could schedule the drug to be taken immediately after breast feeding.
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