Which of the following device-related factors have a major effect on pressurized metered dose inhaler (MDI) delivery of aerosolized drugs during mechanical ventilation?
1. MDI propellant formula
2. Type of spacer or adapter used
3. Position of spacer in circuit
4. Timing of MDI actuation
a. 1 and 3 only
b. 1, 2, and 3 only
c. 3 and 4 only
d. 2, 3, and 4 only
ANS: D
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