How is a type V hypersensitivity reaction different from all other types of known hypersensi-tivities?
A. It is cell-mediated rather than antibody-mediated.
B. This type of reaction is an immediate response rather than a delayed response.
C. The result of the reaction is a stimulatory response to normal tissues rather than an inhibitory response.
D. Type V reactions result in more severe tissue-damaging responses than does any other type of hypersensitivity reaction.
C
Type V hypersensitivity reactions are known as "stimulatory" responses. Currently, the classic example of a type V hypersensitivity is Graves' disease, in which the person makes a large amount of antibody that binds to the thyroid-stimulating hormone receptor (TSHr-Ab) on thyroid tissue. The binding of this antibody to the TSH receptor activates the receptor, greatly stimulat-ing the thyroid gland and causing severe hyperthyroid symptoms.
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