If the pituitary gland is removed from a human subject, which of the following is likely to occur?
A. The adrenal gland will hypertrophy to increase cortisol production.
B. There will be increased negative feedback on growth hormone by insulin-like growth factor 1 (IGF-1).
C. The subject will remain euthyroid.
D. The hypothalamus will secrete less CRH.
E. The adrenal gland will atrophy and plasma cortisol levels will be reduced.
Answer: E
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