A nurse is teaching a nursing student about the effects of a sustained drop in systemic blood pressure on the juxtaglomerular cells of the distal tubules in the kidneys
The nurse knows teaching has been effective when the student identifies which type of medication as one that controls systemic blood pressure?
1. angiotensin converting enzyme (ACE) inhibitor
2. cardiac glycoside
3. thiazide diuretic
4. beta blocker
Correct Answer: 1
A sustained drop in systemic blood pressure triggers the juxtaglomerular cells to release renin. Renin acts on a plasma globulin, angiotensinogen, to release angiotensin I, which is in turn converted to angiotensin II. As a vasoconstrictor, angiotensin II activates vascular smooth muscle throughout the body, causing systemic blood pressure to rise. An angiotensin converting enzyme (ACE) inhibitor blocks the conversion of angiotensin I to the vasodilator angiotensin II. Cardiac glycosides, thiazide diuretics, and beta blockers will not affect the juxtaglomerular cells in the kidneys.
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