Which statement by the nurse is true in regard to the development of a vaccine to prevent HIV?
1. HIV has a low number of genetic variants.
2. HIV has such a slow replication rate.
3. HIV has an extremely rapid replication rate.
4. There is a low mutation rate.
Correct Answer: 3
Rationale 1: HIV has a rapid replication rate, and a high "error" or mutation rate, which creates huge numbers of genetic variants. This causes the vaccine to have to try to hit a "moving target" that is changing genetic makeup every minute.
Rationale 2: HIV has a rapid replication rate.
Rationale 3: HIV has a rapid replication rate.
Rationale 4: HIV has a high "error" or mutation rate, which creates huge numbers of genetic variants.
Global Rationale: HIV has an extremely rapid replication rate, combined with a high "error" or mutation rate.
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