In response to a metabolic acidosis, the kidneys increase the excretion of net acid. Which of the following is the most important component of this compensatory response?
A. increased filtered load of HCO3-
B. enhanced reabsorption of HCO3- by the proximal tubule
C. increased synthesis and excretion of NH4+
D. reduced H+ secretion by the distal tubule and collecting duct
E. reduced secretion of HCO3- by the collecting duct
ANS: C
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