The ventral posterolateral (VPL) nucleus of the thalamus is the site of synapse for:
A. First-order neurons of the dorsal column/medial lemniscus system.
B. Second-order neurons with their cell bodies in the nucleus cuneatus and/or nucleus gracilis.
C. Third-order neurons with their cell bodies in the spinal nucleus of the trigeminal cranial nerve.
D. Second-order neurons with their cell bodies in the nucleus dorsalis (Clarke's nucleus).
E. Third-order neuron with their cell body the lateral cuneate nucleus.
ANS: B
Rationale: Second-order neurons, with their cell bodies located in the nucleus gracilis or nucleus cuneatus, cross the midline as the internal arcuate fibers and ascend to the thalamus as the medial lemniscus. These fibers then synapse with third-order neurons in the VPL nucleus of the thalamus.
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