Ketoconazole (Sporanox) is used as an alternative to amphotericin B for less severe systemic mycosis. The primary reason (or reasons) for choosing ketoconazole is which of the following? (Select all that apply.)
a. Ketoconazole can be given orally.
b. Ketoconazole can be used safely in patients with hepatic dysfunction.
c. Ketoconazole can be given once per week rather than daily.
d. It is the prescriber's choice because the drugs are comparable.
e. Ketoconazole is safer.
A, E
Ketoconazole is given instead of amphotericin B because it is safer and can be administered orally. Amphotericin B is administered intravenously.
Ketoconazole is hepatotoxic. It is given daily.
The drugs are comparable in effect but not in safety.
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