Type 1 fucosidosis is a rare human disease. Patients cannot hydrolyze the disaccharide fucose, and as a result have severe neurological decline and die by age 6. The disease is due to a defect in the gene that encodes the lysosomal enzyme that breaks down fucose (?-1-fucosidase), and is inherited in an autosomal recessive manner. Which of the following statements is accurate about Type 1 fucosidosis?
A. Ff individuals will have the disease, because anyone with the mutant allele will have the disease
B. Ff and ff individuals will have the disease
C. Two carriers for Type I fucosidosis have no chance of having a normal child
D. Ff individuals make enough ?-1-fucosidase to break down fucose and do not exhibit the condition
E. Both Ff individuals will have the disease, because anyone with the mutant allele will have the disease AND two carriers for Type I fucosidosis have no chance of having a normal child
Answer: D
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