Graves' disease is an example of which of the following type II hypersensitivity cytotoxic reactions?
A) Antibodies directly recruit leukocytes to lyse tagged extracellular cells
B) IgM binds to nonsoluble antigens on the surface of a cell causing complement cascade activation to lyse cells.
C) Antibodies interact with a cell-surface receptor on self-cells causing the inactivation of the receptor.
D) IgG binds to nonsoluble antigens on the surface of a cell causing complement proteins to opsonize the target, thereby tagging it for phagocytosis.
E) Antibodies interact with a cell-surface receptor on self-cells causing the overactivation of the receptor.
Answer: E
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