What is "allosteric modulation"?
A. The fact that all binding sites on a protein must be occupied to have a biological effect
B. The ability of a single ligand-binding site to bind to molecularly similar ligands
C. Regulation of physiological functions by the sympathetic division of the autonomic nervous system
D. The change in the shape and functional state of a protein that occurs when a ligand binds to a regulatory site
E. Modification of the functional state of a protein by temperature or pH
Answer: D
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