Describe how exon shuffling could lead to the formation of novel proteins
What will be an ideal response?
ANSWER: Exon-intron junctions often fall at points that divide major functional regions, or domains, in
encoded proteins. Genetic duplications and rearrangements can occasionally cut and paste
parts of different genes together. When the cutting and pasting happens within introns, this
will bring together novel combinations of exons that will produce a new protein. The
individual domains generally retain their specific function in the new protein. This mechanism can produce changes more quickly and more efficiently than random point
mutations that only affect individual amino acids in a protein.
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