For each of the descriptions in questions 5-10, select the molecule involved in T cell traffic (A-L)
A. P-selectin
B. L-selectin
C. CCR8
D. Tumor necrosis factor (TNF)
E. VCAM-1
F. LFA-1
G. CCR5
H. CCR4
?. ?4?7
J. Cutaneous lymphocyte antigen (CLA)
K. Mip1-?
L. VLA-4
Mediates naive CD4+ T cell migration into lymph nodes
ANS: B. L-selectin is expressed abundantly on naive T cells, but not effector T cells, and binds to peripheral lymph node addressin (PNAd) on high endothelial venules in lymph nodes. This adhesive interaction is required for naive T cell migration from blood into lymph nodes, a first step in the initiation of cell-mediated immune responses.
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