A nurse assesses frail older adults prescribed multiple medications. Which of the following pairs of medications are most likely to lead to an adverse drug event causing hospitalization? (Select all that apply.)
A) Atorvastatin (Lipitor) and tamsulosin (Flomax)
B) Ferrous sulfate (Feratab) and vitamin C (L-ascorbic acid)
C) Metformin (Glucophage) and glyburide (Micronase)
D) Naproxen (Naprosyn) and glucosamine (Glucosamina)
E) Warfarin (Coumadin) and clopidogrel (Plavix)
Ans: C, E
Up to 13% of patients taking two medications experience an adverse drug event. Medications most frequently cited as causes of emergency hospitalizations are warfarin, antiplatelet drugs, and antidiabetic drugs, including insulin and oral hypoglycemics.
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