Simple diffusion involves:

A) drugs crossing membranes against their gradient from areas of low concentration to high concentration
B) movement of molecules from areas of higher concentration to areas of lower concentration
C) a certain carrier protein
D) unevenly distributed electrical charges


B) movement of molecules from areas of higher concentration to areas of lower concentration
Simple diffusion involves movement of molecules from areas of higher concentration to areas of lower concentration. Over time, drug molecules are inactivated (metabolized) by tissues, and additional doses may be administered to create a continual concentration gradient, from blood to tissue.

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