A client who has been receiving therapy with tetracycline reports itching and yellowish discoloration of the skin. The nurse knows these symptoms could be associated with which adverse effect of tetracycline?
1. Cholestatic hepatitis
2. Acute pancreatitis
3. Fatty degeneration of the liver
4. Exfoliative dermatitis
Correct Answer: 3
Rationale 1: Cholestatic hepatitis is an adverse effect associated with erythromycin estolate, a macrolide.
Rationale 2: Acute pancreatitis is not associated with tetracycline therapy.
Rationale 3: Pruritus, or itching, and jaundice, a yellowish discoloration of the skin, are associated with fatty degeneration of the liver, a serious adverse effect of tetracycline.
Rationale 4: Exfoliative dermatitis is an adverse effect associated with tetracycline. However, it is associated with pruritus, not jaundice.
Global Rationale: Serious adverse reactions of tetracycline include anaphylaxis; fatty degeneration of the liver, producing jaundice; and exfoliative dermatitis. Cholestatic hepatitis is an adverse effect associated with erythromycin estolate, a macrolide. Acute pancreatitis is not associated with tetracycline therapy. Exfoliative dermatitis is an adverse effect associated with tetracycline. However, it is associated with pruritus, not jaundice.
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