Which of the following newest antipsychotic drugs has been publicized as having the greatest risk for severe agranulocytosis and severe bone marrow depression and requires carefully controlled laboratory monitoring?
a. clozapine (Clozaril)
b. risperidone (Risperdal)
c. olanzapine (Zyprexa)
d. quetiapine (Seroquel)
A
Clozapine has been publicized as having the greatest risk for severe agranulocytosis and severe bone marrow depression. 1% to 2% of persons taking clozapine develop bone marrow suppressions. For this reason, safe use of clozapine requires weekly monitoring of the individual's white blood cell count for the first 6 months of therapy.
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