The patient has meningitis. The physician initially prescribed a water-soluble drug. Another physician changed the order to a lipid-soluble drug. The patient is confused about this. Which plan best resolves the patient's concern?
1. Teach the patient that lipid-soluble drugs are better because of protein binding.
2. Teach the patient that lipid-soluble drugs are more effective in treating his illness.
3. Teach the patient that lipid-soluble drugs are better because they have fewer side effects.
4. Teach the patient that lipid-soluble drugs are more effective because they are excreted at a slower rate.
2
Rationale 1: Not all lipid-soluble drugs are protein bound.
Rationale 2: Drug molecules that are lipid soluble will usually pass through plasma membranes by simple diffusion and more easily reach their target cells.
Rationale 3: Lipid-soluble drugs do not necessarily have fewer side effects. Not all lipid-soluble drugs are protein bound.
Rationale 4: Lipid solubility does not affect drug excretion.
Global Rationale: Drug molecules that are lipid soluble will usually pass through plasma membranes by simple diffusion and more easily reach their target cells. Lipid-soluble drugs do not necessarily have fewer side effects. Not all lipid-soluble drugs are protein bound. Lipid solubility does not affect drug excretion.
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