Which of the following statements explains why diphenhydramine (Benadryl) should be used with extreme caution in clients with Alzheimer's disease?
A) Diphenhydramine causes dizziness and can lead to falls.
B) Diphenhydramine interferes with the acetylcholine available for neural transmission.
C) Diphenhydramine can cause respiratory distress secondary to histamine release.
D) Diphenhydramine can impede cerebral blood flow in susceptible people.
Ans: A
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One of the most common anticholinergic medications is diphenhydramine (Benadryl), available OTC and used for allergy reactions and as a sleep aid. Because of its side effects, many people who use diphenhydramine begin to feel dizzy and lightheaded, get a dry mouth, and sometimes become confused and disoriented. Older adults who already have confusion and disorientation secondary to Alzheimer's disease will be compromised significantly if they take anticholinergic drugs. In addition to decreased cognition and confusion, other anticholinergic effects such as dry mouth, dizziness, and blurred vision can predispose older clients to falls. Even if they do not have Alzheimer's disease, giving anticholinergics routinely to any older adult is dangerous.
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