A patient admitted to the medical-surgical unit is being treated with warfarin (Coumadin) for prevention of thrombus. The patient develops hyperuricemia, and allopurinol (Zyloprim) is prescribed
The nurse should anticipate which change in the drug regimen?
a. Reduction of the warfarin dose
b. Increase in the warfarin dose
c. Discontinuation of the allopurinol
d. Increase in the allopurinol dose
ANS: A
The nurse should anticipate a reduction in the warfarin dose, because allopurinol may enhance its effects.
Increasing the dose of warfarin would further increase the risk for bleeding while the patient is receiving allopurinol.
Because the patient needs treatment for hyperuricemia, discontinuing the allopurinol is not feasible; therefore, other options need to be considered.
Increasing the dose of allopurinol would further potentiate the effect of warfarin.
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