Order: DTIC-Dome (dacarbazine) 250 mg/m IV for five days. The label on the vial reads 100 mg, and the manufacturer's directions states to reconstitute with 9
9 mL of sterile water for injection, yielding a strength of 10 mg/mL, further dilute in 250 mL of D5W, and infuse over 60 minutes. Calculate the rate of flow in milliliters per hour for a patient who weighs 92 kilograms and is 183 centimeters tall. 1. 250 mL/h
2. 304 mL/h
3. 367 mL/h
4. 540 mL/h
2
Global Rationale: 2.16 m2 × 250 = 540 mg; 54 mL + 250 mL = 304 mL.
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