People who are heterozygous for HLA-DQ2 and HLA-DQ8 allotypes are at greater risk of developing type 1 diabetes than those who are homozygous for HLA-DQ2 or HLA-DQ8
A. Explain the reason for this increased susceptibility.
B. Why is the above statement true mainly for people of northern European origin but not for some other ethnic groups?
A. Increased risk of developing type 1 diabetes is associated with the formation of a heterozygote-specific heterodimer composed of the HLA-DQ8α chain DQA1*03 and the HLA-DQ2β chain DQB1*02:01.
B. In northern Europeans this combination of α and β chains is never encoded in the same haplotype, so it can be produced only in heterozygotes. Haplotypes containing both susceptibility alleles can, however, be present in Africans, and similarly confer susceptibility to type 1 diabetes.
You might also like to view...
Convert the decimal to a fraction. 7.2
A) 7 1/25 B) 7 1/10 C) 7 2/25 D) 7 1/50 E) 7 1/5
____________________ is the use of ultrasound imaging to create a visual image of the brain for diagnostic purposes.?
Fill in the blank(s) with correct word
____________________ syndrome occurs when the tendons of the wrist become inflamed and swollen.?
Fill in the blank(s) with correct word
Which of the following external female genitals are folds of mucous membrane?
A) Labia minora B) Labia majora C) Mons pubis D) Clitoris